by Kraneshares
info@kraneshares.com China Healthcare: Potential Opportunities From One Of The Fastest Growing Major Global Healthcare Markets1 An Overview of the KraneShares MSCI All China Healthcare Index ETF (Ticker: KURE) KURE 9/30/2026
![]()
pocket healthcare spendi ng at just over $298, 1 compared to an average of $1,200 among the Organization for Economic Cooperation and Development (OECD) countries. 2 • China’s aging population, rising incomes, and increasing urbanization may provide a sustained catalyst for growth in China’s hea lthcare sector. KURE features: • Exposure to Chinese companies listed in Mainland China, Hong Kong, and the United States that are involved in the healthcare ind ustry. • Exposure to key healthcare subsectors: Biotechnology, General Pharmaceuticals, Care Providers, Medical Devices, and Tradition al Chinese Medicine. • Exposure to companies that may benefit from China’s growing middle class and aging population. • Access to major global healthcare companies that are often not captured by broad indexes. KraneShares MSCI All China Healthcare Index ETF KURE 1. Data from CEIC, Statista, Caixin Global, and the World Bank as of 12/31/2025. Retrieved on 9/30/2026. 2. Data from OEC and the World Bank as of 12/31/2025. Includes estimates. Retrieved on 9/30/2026.
![]()
Data from the National Bureau of Statistics of China as of 12/31/2025. Retrieved on 9/30/2026. 2. Data from OECD as of 12/31/2025. 3. Data from Statista as of 12/31/2025. Retrieved on 9/30/2026. An aging population means a growing healthcare market. • China's population is aging rapidly, and this demographic shift is likely to have significant implications for the country's hea lthcare system. • China’s population aged 60 and older reached 323.38 million in 2025, accounting for 23.0% of its total population. 1 • China’s healthcare expenditure is still small compared to the OECD average. 2 3 0 100 200 300 400 500 600 2025 2050 Projection Millions Number of People aged 60+3 0 2 4 6 8 10 12 14 16 18 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 % Population in China aged 65+ as % of T otal Population3
![]()
pocket expenditure and covered costs. Please see the end of t he presentation for definitions. +8% CAGR +27% CAGR China’s health expenditure could surge in the coming years due to demographic changes and rising incomes. 4
![]()
China healthcare stocks have exhibited low correlations to both broad-based global benchmarks and global healthcare benchmark since KURE’s inception in 2018. Correlation KURE S&P Biotech Index S&P Global Health Care 1,200 Index S&P 500 Index MSCI ACWI Index KURE 1 S&P Biotech Index 0.38 1 S&P Global Health Care 1,200 Index 0.35 0.61 1 S&P 500 Index 0.33 0.60 0.98 1 MSCI ACWI Index 0.37 0.62 0.99 0.97 1 Weekly Correlation Since KURE Inception (12/31/2018 – 9/30/2026) Data from Bloomberg as of 9/30/2026. Please see the end of the presentation for index and term definitions. 5
![]()
communicable diseases such as cancer. • In 2016, the government responded to growing healthcare concerns by launching the “Healthy China 2030 Plan,” a national initi ati ve that promotes diet, exercise, and access to healthcare services. Data from the National Bureau of Statistics of China and Statista as of 12/31/2025. Please see the end of the presentation fo r d efinitions. 189 300 452 658 823 842 861 883 898 927 943 953 0 200 400 600 800 1000 1200 Population in Millions China Urban Population 20,000 25,000 30,000 35,000 40,000 45,000 RMB Disposable Income of Urban Households in China
![]()
universal access to healthcare services. 2 1. Data from Statista, Trivium China as of 12/31/2025. Retrieved on 9/30/2026. 2. National Healthcare Security Administration, "China's basic medical insurance covers 95 pct of population", The State Council of the People's Republic of China, Jul. 2025. Retrieved on 9/30/2026. The expansion of the scope of centralized drug and device approvals and purchasing led to a sales slump in the short term. Launch of “Healthy China 2030 Plan” Sales return to growth. 0 200 400 600 800 1,000 1,200 Billions of RMB China T otal Annual Pharmaceutical Sales
![]()
8 We believe that, since 2021, the share price performance of China‘s health care companies has become disconnected from earnings growth. Data from KraneShares and Bloomberg as of 6/30/2026. Retrieved on 9/30/2026 The performance data quoted represents past performance, and current returns may be higher or lower . Past performance does not guarantee future results. For additional performance and information, please see slide 21. Index performance is for illustrative purposes only. Indexes are unmanaged and one cannot invest directly in an index. Index returns do not reflect fees or other costs associated wi th investing. Please see the end of the presentation for definitions. $- $5,000 $10,000 $15,000 $20,000 $25,000 $30,000 $35,000 $- $5 $10 $15 $20 $25 $30 $35 $40 $45 $50 6/1/2018 1/1/2019 8/1/2019 3/1/2020 10/1/2020 5/1/2021 12/1/2021 7/1/2022 2/1/2023 9/1/2023 4/1/2024 11/1/2024 6/1/2025 1/1/2026 Millions KURE Price China Health Care (T otal earnings before interest and taxes (EBIT) vs. Price) Total EBIT (Right Axis) KURE Price (Left Axis) $- $50,000 $100,000 $150,000 $200,000 $250,000 $300,000 $350,000 $400,000 $450,000 $500,000 0 1,000 2,000 3,000 4,000 5,000 6,000 9/1/2018 4/1/2019 11/1/2019 6/1/2020 1/1/2021 8/1/2021 3/1/2022 10/1/2022 5/1/2023 12/1/2023 7/1/2024 2/1/2025 9/1/2025 4/1/2026 Millions Index Level S&P Global 1,200 Health Care Index (T otal EBIT vs. Price) EBIT (Right Axis) Price (Left Axis)
![]()
9 China’s Healthcare Ecosystem General Pharmaceuticals Medical Devices Care Providers Biotechnology Traditional Chinese Medicine
![]()
Positive Advanced NSCLC,” IASLC. September 12, 2026. Retrieved on 9/30/2026. Holdings are subject to change. Please see page 21 for top 10 holdings.
![]()
11 Innovent Biologics has increased revenues ninefold since 2019. The biotechnology firm has developed one of the most effective treatments for lung cancer. Biotechnology Data from Bloomberg as of 12/31/2025. Retrieved on 9/30/2026. Please see the end of the presentation for definitions. Holdings are subject to change. See page 21 for top 10 holdings 0 2 4 6 8 10 12 14 2019 2020 2021 2022 2023 2024 2025 RMB, Billions Innovent Biologics' Annual Revenue
![]()
1/GIP therapy, outside Greater China. The deal includes $300 million upfront and potential total payments of up to $2.6 billion, plus royalties.² Definitions: • Out-Licensing: The practice of selling pharmaceuticals or medical devices developed in China in international markets. • In-Licensing: The practice of selling pharmaceuticals or medical devices developed in international markets in China.
![]()
13 The number of out-licensing deals has increased in recent years, leading to an even more global customer base for China’s pharmaceutical firms. Data from CLSA, McKinsey, Pharma DJ, Pharmavoice , Pharmasource , and PharmCube as of 12/31/2025. Includes estimates. General Pharmaceuticals 2 10 12 21 42 48 73 70 186 37 64 85 83 128 66 170 19 20 0 50 100 150 200 250 300 2017 2018 2019 2020 2021 2022 2023 2024 2025 No. of China Drug Licensing Deals: In vs. Out Out-Licensing In-Licensing
![]()
vitro fertilization equipment, ventilators, among other key medical devices. China’s medical device market is world-class with both domestic and international customer bases. Holdings are subject to change. See page 21 for top 10 holdings.
![]()
15 Medical Devices Global medical devices giant Mindray has doubled its revenue since 2019. Data from Bloomberg as of 12/31/2025. 2025 revenue is estimated. Please see the end of the presentation for definitions. Holdings are subject to change. See page 21 for top 10 holdings. 0 5 10 15 20 25 30 35 40 2019 2020 2021 2022 2023 2024 2025 RMB, Billions Mindray Annual Revenue
![]()
year history encompassing herbal medicine, acupuncture, massage and dietetics. • In December 2016, China’s State Council issued the “Strategic Plan on the Development of Traditional Chinese Medicine,” making the development of TCM a national strategy. The policy emphasizes promoting a balance between Western medicine and TCM practices. • TCM has a global footprint, and the global TCM market was valued at $86 billion in 2025. 1 • TCM practitioners emphasize preventative medicine and treating diseases before they occur through healthy living and proper diets. This is especially important in China, which has increased obesity, diabetes, and smoking rates. • TCM companies can also benefit from increasing incomes and consumer spending, as many TCM products are popular for personal wellness purposes rather than urgent medical needs. 1. Forecast from Mordor Intelligence as of 12/31/2025. Holdings are subject to change. See page 21 for top 10 holdings. The Traditional Chinese Medicine (TCM) industry represents a sizable portion of the entire market. TCM has over 2,000 years of tradition In Traditional Chinese Medicine, good health is believed to be achieved by a balance between yin and yang. Traditional Chinese Medicine Traditional Chinese Medicine Tong Ren Tang manufactures and sells traditional remedies in China and abroad.
![]()
17 Care Providers As China’s population becomes more health conscious, the demand for high quality preventative care also increases, providing a catalyst for private hospitals and facilities that offer health examinations, evaluations, and consulting services. Privatization • Rising demand from wealthier Chinese seeking quality care and diverse services has led to increased privatization of hospitals to match demand, but public hospitals still far outnumber private hospitals. • We believe China’s public hospital system will be insufficient to satisfy the need of the population through 2050, leading to the establishment of more private hospitals. Healthy China 2030: Upgrading Primary Care Institutions • The “Healthy China 2030” policy outlines the government’s plans to upgrade the standards and quality of service in primary care institutions. • The government sees general practitioners as the gatekeepers of people's health and primary method of controlling medical expenditures. • By 2030, the goal is to have five qualified general practitioners available for every 10,000 residents in China. 1 • The National Health and Family Planning Commission estimates China needs to add 210,000 general practitioners. 1 • The establishment of a medical network and referral system may help reduce overcrowding in China’s largest tertiary hospitals. 1. Healthy China 2030 Plan. Retrieved 9/30/2026. Holdings are subject to change. See page 21 for top 10 holdings. Care Provider Aier Eye Hospital is a leading private ophthalmic healthcare provider in China and globally. As of December 31, 2025, Aier operated 663 ophthalmic facilities in Mainland China, 151 in Europe, 9 in Hong Kong, 18 in Southeast Asia, and one in the United States. Company data as of 12/31/2025. Retrieved 9/30/2026
![]()
Example Holdings in the KraneShares MSCI All China Healthcare Index ETF (Ticker: KURE) Data from Bloomberg and KraneShares as of 9/30/2026. Please see page 21 for top 10 holdings. Holdings subject to change. Please see the end of the presentation f or definitions.
China comparable companies are included for illustrative comparison purposes only and are not holdings of KURE as of Septemb er 30, 2026. Historical company revenue growth is not indicative of future results or Fund performance. Subsector Example Holding Holding weight (as of 9/30/2026) Logo 5-Y ear Average Revenue Growth Ex-China Comparable Company Logo 5-Y ear Average Revenue Growth General Pharma. Jiangsu Hengrui 4.46% 3.69% P fizer 16.63% Medical Devices Mindray 4.37% 10.23% Thermo Fisher Scientific 7.13% Care Providers Aier Eye Hospital 1.74% 13.86% Community Health Systems 1.18% Biotech BeOne 8.82% 94.30% Gilead Sciences 3.67% Traditional Chinese Medicine Tong Ren Tang 0.76% 7.54% Natural Alternatives International 4.81% 18
![]()
19 Many of China’s leading healthcare companies operate and serve customers globally . Nonetheless, they are under allocated to in global healthcare portfolios. Country No. of Facilities USA 3 Germany 1 Ireland 1 Singapore 2 Country No. of Facilities USA 5 Switzerland 1 Country No. of Facilities USA 3 Market Cap ($, Billions) 23 % of S&P Global Health 0 Market Cap ($, Billions) 71 % of S&P Global Health 0 Market Cap ($, Billions) 30 % of S&P Global Health 0 Data from Bloomberg, Company Websites as of 9/30/2026. S&P Global Health = S&P Global Healthcare 1,200 Index. Please see the end of the presentation for definitions. Holdings are subject to change. See page 21 for top 10 holdings.
![]()
KURE Portfolio Characteristics Market Cap Breakdown Listing Location Breakdown Data from FactSet, Bloomberg, and KraneShares as of 9/30/2026, excluding cash. Portfolio allocations and holdings are subject to change. See page 21 for top 10 holdings 20 Subsector Breakdown Large Cap 93% Mid Cap 7% Hong Kong 57% Mainland China 42% United States 1% General Pharmaceuticals 28% Biotechnology 57% Medical Devices 9% Care Providers 2% Traditional Chinese Medicine 5%
![]()
8.23 % 0.13 % The performance data quoted represents past performance. Past performance does not guarantee future results. The investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than their original cost and current performance may be lower or higher than the performance quoted. For performance data current to the most recent month end, please visit www.kraneshares.com/kure. Index returns are for illustrative purposes only. Index performance returns do not reflect any management fees, transaction costs or expenses. Indexes are unmanaged and one cannot invest directly in an index. * Fee waivers are contractual and in effect until August 1, 2028 . Closing Price returns use the official ETF closing price or, if unavailable, the NBBO midpoint when NAV is calculated, and ma y d iffer from returns received at other trading times. NAVs use prices as of 4:00 p.m. Eastern Time. 21
![]()
KraneShares Empowering investors with access to the world’ s most powerful growth themes through ETFs, private strategies, and innovative investment solutions. 22
![]()
Commerce China A SharesKBA / CHIN KCAI China Onshore Alpha Index AGIX Artificial Intelligence & Technology KOID Humanoid & Embodied Intelligence Electric Vehicles & Future MobilityKARS China Suite Future T ech Broader Emerging Markets KEMQ Emerging Markets Consumer Tech KPHO Dragon Capital Vietnam Growth KEMX MSCI Emerging Markets ex China U.S. & Developed Markets KVLE Value Line ® Dynamic Dividend Equity Hedgeye Hedged EquityKSPY Man Buyout Beta IndexBUYO Fixed Income BNDD Quadratic Deflation ETF IVOL Quadratic Interest Rate Volatility & Inflation Hedge KHYB Asia High Income USD Bond Sustainable Ultra Short DurationKCSH KEUA European Carbon Allowance Global Carbon StrategyKRBN Carbon Credits KPDD 2X Long PDD Daily KJD 2X Long JD Daily KBAB 2X Long BABA Daily KMLI 2X Long MELI Daily Covered Call & Options Income Managed Futures KMLM Mount Lucas Managed Futures KWIN Wahed Alternative Income KLIP China Internet & Covered Call Outcome Based Equity KIQQ Nasdaq Buffer & Option Income Levered & High-Conviction Exposure KBUF 90% KWEB Defined Outcome 100% KWEB Defined OutcomeKPRO Alternative Income KCCA California Carbon Allowance Extensive ETF Product Suite Spanning High Growth Sectors Strategy also available in UCITS / ETC KBDU 2X Long BIDU Daily 23
![]()
1 indicating a perfectly inverse relationship, 0 indicating no synchronization whatsoever, and 1 indicating they always move in lockstep with one another. 24
![]()
Important Notes: Carefully consider the Funds’ investment objectives, risk factors, charges and expenses before investing. This and additional information can be found in the Funds' full and summary prospectus, which may be obtained by visiting www.kraneshares.com/kure/ Read the prospectus carefully before investing. Risk Disclosures: Investing involves risk, including possible loss of principal. There can be no assurance that a Fund will achieve its stated objectives. Indices are unmanaged and do not include the effect of fees. One cannot invest directly in an index. This information should not be relied upon as research, investment advice, or a recommendation regarding any products, strategies, or any security in particular. This material is strictly for illustrative, educational, or informational purposes and is subject to change. Certain content represents an assessment of the market environment at a specific time and is not intended to be a forecast of future events or a guarantee of future results; material is as of the dates noted and is subject to change without notice. The Fund may invest in derivatives, which are often more volatile than other investments and may magnify the Fund’s gains or losses. A derivative (i.e., futures/forward contracts, swaps, and options) is a contract that derives its value from the performance of an underlying asset. The primary risk of derivatives is that changes in the asset’s market value and the derivative may not be proportionate, and some derivatives can have the potential for unlimited losses. Derivatives are also subject to liquidity and counterparty risk. The Fund is subject to liquidity risk, meaning that certain investments may become difficult to purchase or sell at a reasonable time and price. If a transaction for these securities is large, it may not be possible to initiate, which may cause the Fund to suffer losses. Counterparty risk is the risk of loss in the event that the counterparty to an agreement fails to make required payments or otherwise comply with the terms of the derivative. The ability of the Fund to achieve its respective investment objectives is dependent, in part, on the continuous availability of A Shares and the ability to obtain, if necessary, additional A Shares quota. If the Fund is unable to obtain sufficient exposure to limited availability of A Share quota, the Fund could seek exposure to the component securities of the Underlying Index by investment in other types of securities. The Fund is subject to political, social or economic instability within China which may cause decline in value. Emerging markets involve heightened risk related to the same factors as well as increase volatility and lower trading volume. Fluctuations in currency of foreign countries may have an adverse effect to domestic currency
values. The Fund may invest in Initial Public Offerings (IPOs). Securities issued in IPOs have no trading history, and information about the companies may be available for very limited periods. In addition, the prices of securities sold in IPOs may be highly volatile. In addition, as the Fund increases in size, the impact of IPOs on the Fund’s performance will generally decrease. Narrowly focused investments typically exhibit higher volatility. The Fund’s assets are expected to be concentrated in a sector, industry, market, or group of concentrations to the extent that the Underlying Index has such concentrations. The
advisers for the Funds. 25
![]()